Charming and historic City Drug Store in Wheeler, TX, was re-built in 1924 after the original wooden structure burned. The cement block structure served the community as a ‘drug store’ and ‘soda shop’ for the next 50 years. In the 1930′s, the first floor was enlarged for Doctors’ offices and the second story was added to serve as the town’s first hospital. In the 1940′s, the second floor was converted into apartments and many couples began married life on the second floor of the City Drug Store.

In the 1950′s, the apartments were abandoned and the second floor remained unused for 50 years.  The City Drug Store continued in business until 1973. The building was vacated in 1993 and remained empty until Jim and Bobbye Hill bought the building and began remodeling the building for the “City Drug Bed and Breakfast Hotel”.